One of the oldest largely intact residences in Santa Fe, the Gregorio Crespin House is an eighteenth-century adobe home that passed from generation to generation of Spanish Colonial, Native American, and Anglo-American owners. The land on which the house is located was granted by General Don Diego de Vargas to Juan de León Brito, a Tlaxcalan Indian who participated in the reconquest of Santa Fe in 1693. Gregorio Crespin, born in 1707, built a two-room house on the site between 1720 and 1750. By 1867, it was expanded into a five-room house with additions of a portal with Territorial Style columns, brick coping at the parapet, and a small placita. By 1914–16, the home included twelve rooms. The Gregorio Crespin House was placed on the National Register of Historic Places in 1975 for its architectural significance.

From Old Santa Fe Today, 5th edition by Audra Bellmore with photographs by Simone Frances.